Neuramis Filler 5,990.-/cc. Please add LINE

Smile Line Fillers: Instantly Restore Youthful Looks

If you look in the mirror or take a photo and see deep smile lines even when you're not smiling, it might be a sign of an aging face. This can make you look serious and unfriendly, affecting your confidence.

But today, the beauty industry offers a solution for deep smile lines that doesn’t require a lot of pain and shows immediate results. This treatment can last for an average of 8-12 months. The solution is injecting smile line fillers.

Select a Topic to Read

Explore the problem of deep smile lines: Can smile line fillers really help?

What causes smile lines?

Smile lines are the folds or lines that run from the sides of your nose to the corners of your mouth. Normally, they appear when you smile, laugh, chew, or talk. If you start noticing these lines even when you’re not making facial expressions, it might mean your face is aging due to several reasons

The bones under the eyes are shrinking
The upper cheek tissues sag down over the smile lines, making them more prominent.
The bones around the smile lines shrink
This is often seen in people aged 20-30, making their smile lines deeper.
Frequent smiling
This causes the muscles to be overused, similar to how facial expressions cause wrinkles.
Dry skin
Lack of moisture in the skin leads to lines along the smile lines.

How to fix smile lines?

Injecting smile line fillers

Filler Injection is the process of injecting Hyaluronic Acid (HA), a substance naturally found in the skin tissues that helps keep the skin hydrated, firm, and elastic. It has the ability to retain water and expand.

To address deep smile lines, doctors inject fillers into the main areas

Injecting fillers to support the bones around the smile lines
This lifts the sagging cheek tissues above the smile lines, making the lines less noticeable.
Injecting fillers into the skin around the smile lines
This compensates for the lost collagen and fat under the skin as we age, making the lines look fuller and smoother. It also adds moisture to the skin and reduces the chance of new deep lines forming.

Who should get smile line fillers?

People with deep smile lines that make their face look serious and unfriendly
This can cause annoyance and a lack of confidence, especially when taking photos.
People who are getting older and have sagging cheek skin
They might need smile line fillers along with skin-tightening procedures.

Solve sagging skin, the cause of deep smile lines that age your face

The sagging skin under the eyes and cheeks, due to reduced collagen, accumulates in the smile lines, making them more prominent. If left untreated, the smile lines will deepen, making the face look older and more tired.

Injecting smile line fillers might not be the only solution. Experienced doctors often recommend Mid Cheek Filler to lift the skin or regularly doing Ultraformer III treatments to firm the cheek area.

Things to know before deciding on smile line fillers

Are smile line fillers safe?

Hyaluronic Acid (HA) fillers have been used for decades to correct facial shapes and enhance beauty. They are widely recognized in dermatology and considered very safe. However, the dangers associated with fillers often come from three major issues

Non-standard clinics that usually offer suspiciously low prices
Inexperienced doctors or non-doctors administering the injections
Clinics using counterfeit fillers, illegal drugs, or smuggled drugs with unknown sources

Therefore, before deciding on filler injections, you should thoroughly research the procedure and the clinic. Ensure that a qualified doctor will perform the injections, that the fillers used are genuine and verifiable, and that there is a follow-up service and attentive consultation from the staff.

Will smile line fillers cause lumps?

After injecting the smile lines, the filler takes about a month to fully set and blend with the skin. However, if the doctor is skilled and chooses the appropriate filler type, the chance of the filler forming lumps is very low.

Which brand of fillers is the best?

At MEGA Clinic, we offer 3 leading brands of fillers: Neuramis from Korea, Restylane from Sweden, and Juvederm from the USA.

Among all these fillers, Neuramis is the most popular with MEGA CLINIC clients due to its noticeable results in smoothing deep smile lines and its affordable price.

Post-treatment care for smile line fillers

Drink plenty of water, 8-10 glasses a day, especially for the first 4 weeks after the treatment. This helps the fillers blend smoothly with your skin.
Avoid massaging or pressing hard on the area where the filler was injected for 1 month to prevent the fillers from losing shape.
Avoid high heat like lasers, saunas, and steam rooms for 1 week to keep the fillers from dissolving too quickly.
If you feel tightness in the smile lines or have a headache after the injection, take painkillers. The discomfort should ease in 2-4 weeks.

Q&A Knowledge about smile line filler injection

Q: I have deep smile lines after finishing braces. Can fillers help?

A: Yes, many people notice more prominent smile lines during or after having braces. Injecting smile line fillers can help fill and smooth these lines, giving your face a younger appearance.

Q: Neuramis fillers come in black and gold packaging. What’s the difference?

A: The black box is Neuramis Deep, while the gold box is Neuramis Volume, which is slightly softer in texture than the black one. The doctor will assess your chin’s skin structure before recommending the most suitable filler for you.

Q: Does smile line filler injection hurt? Do the fillers contain anesthetic?

A: Both Neuramis Deep (black box) and Neuramis Volume (gold box) contain anesthetic (Lidocaine).

Additionally, doctors often use the cannula injection technique for this area. Cannulas are blunt-tipped needles that can navigate under the skin more safely. This technique reduces the risk of piercing blood vessels, minimizes pain during the procedure, and lessens bruising after treatment.

Q: How long does a smile line filler injection take?

A: The procedure takes about 20–30 minutes, not including the time for applying numbing cream. After the injection, you can resume your normal activities immediately.

Q: Are there other treatments that can address smile lines directly or indirectly?

A: Two additional treatments that can help with smile lines are Sculptra, which stimulates collagen production to improve skin volume and elasticity, and Ultraformer III, which uses focused ultrasound to tighten and lift sagging skin, reducing the depth of smile lines.

Doctors will carefully evaluate your facial structure and skin condition to recommend the most suitable option—be it fillers, Sculptra, or Ultraformer III.

You might want to read:

How to Treat Smile Lines and Prevent an Aged Appearance

10 Must-Know Q&A About Smile Line Filler

Smile line fillers reviews

Cost of smile line fillers

*All promotions end on December 31, 2025. Screenshot and ask to claim your deal. Click here!

you can get a free consultation at any of MEGA CLINIC's 5 branches:

Aesthetic clinic, MEGA CLINIC, Siam Square.

Aesthetic clinic, MEGA CLINIC, Nonthaburi

Aesthetic clinic, MEGA CLINIC, Lad Prao

Aesthetic clinic, MEGA CLINIC, Pathum Thani

Aesthetic clinic, MEGA CLINIC, Pak Nam (Srinagarindra)

You can also get an initial consultation with Mega Clinic's admin team via LINE Official: @megaclinic (with @), or click the green button below to add us on LINE.