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Smile Lines Making You Look Older? Are Filler Programs the Right Choice? Benefits, Risks, and What to Expect

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What are smile lines?

Smile lines (also called nasolabial folds) are the creases that run from the sides of the nose to the corners of the mouth. Normally, they appear when you smile, laugh, or move your facial muscles. But if these lines are visible even when your face is at rest, it may be a sign that the skin and bone structure are changing, making the face look older.
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What causes deep smile lines?

Several factors can make smile lines deeper and more noticeable:
  • Bone loss under the eyes: Without support from the underlying bone, the skin around the cheeks sags and folds more deeply above the smile lines.
  • Bone loss around the smile lines: This can begin as early as your 20s–30s. Even if it’s not severe, it can make the lines more visible.
  • Repeated facial movement: Smiling and laughing frequently creates creases that become deeper with age, especially as collagen and facial fat decrease.
  • Skin damage and dryness: Sun exposure and UV damage weaken the skin, leading to fine lines along the smile folds that can develop into deeper wrinkles.

Is it normal to have smile lines at a young age?

Smile lines aren’t just for older people. Younger individuals can also develop them due to factors like frequent smiling and laughing, sleeping on the side or face-down, poor skincare habits, lack of sleep, dehydration, rapid weight loss, or simply genetics and natural facial structure.
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Why do filler injection programs help reduce smile lines?

One of the most popular treatments for smile lines is the filler injection program. By injecting hyaluronic acid (HA) into the folds, the skin becomes smoother and fuller right away, giving the entire face a fresher, younger appearance.
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HA filler program is designed to mimic the body’s natural HA. They are FDA-approved in Thailand and internationally for safety. Filler program helps plump deep folds, restore lost volume, lock in moisture, and improve skin elasticity. Over time, they dissolve naturally and leave no residue.

Real customer reviews: Smile line filler programs at MEGA CLINIC

Who should consider smile line filler programs?

  • People with deep smile lines that make them look harsh, unfriendly, or less confident, especially in photos
  • Those who notice smile lines becoming obvious with age, even when the face is at rest
  • People whose makeup doesn’t sit well, as foundation sinks into deep folds
  • Individuals with sagging cheeks that make smile lines more prominent (may also need skin-tightening treatments)
  • Professionals or people often on camera who want a quick, natural-looking fix
Filler program can be done from age 18 and above. Even younger clients with visible smile lines can consult a doctor to check if the treatment is suitable.

Is smile line filler program safe?

Hyaluronic acid (HA) filler program has been used for decades to restore facial volume and is widely accepted in dermatology worldwide. It is considered a very safe procedure. Cases of unsafe filler injection programs usually come from three major issues:
  • Non-standard clinics that usually offer suspiciously low prices
  • Inexperienced doctors or non-doctors administering the injections
  • Fake or unapproved products with unclear origins
Before any treatment, it’s important to research the clinic carefully. Make sure the injections are performed by a licensed doctor and that only genuine, verifiable products are used. If the clinic cannot guarantee these, it’s safer to choose a certified and trusted provider instead.

How many CCs are needed for deep smile lines?

The amount depends on the depth and severity of each person’s folds. Doctors adjust to ensure a natural result. On average, 2–4 CCs are typically used.

How long does the smile line filler program last?

Filler program gradually settles and shows full results within about 1 month. On average, results last 8–12 months, as HA naturally breaks down in the body.

When can you repeat the injection? Is it safe to do it often?

The breakdown rate varies based on lifestyle, metabolism, and facial movement, especially since the mouth area moves frequently (talking, chewing, smiling). This often makes HA filler program in this area last slightly shorter than in other zones.
For continuous youthful results, top-ups every 8–12 months are recommended, or whenever lines become noticeable again.
Because genuine HA filler programs are biocompatible with the body, they can be safely repeated under a doctor’s care.

Smile lines, sagging cheeks, and loose skin—What’s the best solution?

The right treatment depends on each person’s skin condition. Doctors will design a plan tailored to the problem.
For direct smile line correction:
  • Smile line filler program Instantly plump and smooth deep folds, restoring freshness.
  • Program HArmonyCa A blend of HA and CaHA that not only fills but also stimulates collagen for longer-lasting firmness.
For sagging cheeks (a common cause of deeper smile lines):
  • Ultraformer III program Uses ultrasound energy to lift and stimulate collagen, reducing sagging and slowing down the formation of deeper folds.
  • Midface filler program Add volume and support to the cheeks, suitable for early smile lines caused by flat or hollow midface.

Which filler program brands are best for deep smile lines? Is Neuramis a good option?

At MEGA CLINIC, our doctors recommend three trusted filler program brands for treating deep smile lines:
  • Neuramis (Korea) – Imported by MEDYCELES (Thailand)
    Known for reliable quality and affordable pricing, making it the most popular choice.
  • Restylane (Sweden) – Imported by GALDERMA (Thailand)
    A premium brand, recognized worldwide for its advanced production technology.
  • Juvederm (USA) – Imported by ALLERGAN (Thailand)
    High-quality brand, praised for their natural-looking results and smooth finish.
Among these, Neuramis is the No.1 Korean filler program brand, with the most popular Neuramis Deep (Black Box). Its gel texture is suitable for multiple areas of the face, including smile lines, providing natural, noticeable results at an accessible price—making it one of the best value options today.

Pre- and post-care tips for smile line filler program

Before filler programs, to reduce the chance of noticeable bruising, prepare by:
  • Avoiding painkillers such as Aspirin and NSAIDs for about 2 weeks
  • Stopping certain supplements like Vitamin E, Vitamin K, fish oil, and Primrose for about 2 weeks
  • Avoiding alcohol for at least 24 hours, as it dilates blood vessels and may increase bruising
After getting  proper aftercare helps HA settle and last longer. Be sure to:
  • Do not press, massage, or squeeze the treated area for 1 month
  • Avoid high-heat treatments like lasers, saunas, or steam rooms for at least 1 week
  • Drink at least 8 glasses of water daily to help HA stay hydrated and settle smoothly into the skin
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Other than that, you can continue your daily routine as usual like washing your face, applying skincare, using masks, or being around regular heat such as warm showers, cooking, or eating hot food.

Key benefits of treating deep smile lines with filler program

  • Directly improves age-related skin changes and facial bone loss
  • Instantly softens deep folds for a fresher, younger look
  • Restores volume, boosts hydration, and supports collagen for plumper, more elastic skin
  • Reduces fine lines around the folds, helping prevent permanent wrinkles
  • Safe, convenient, non-surgical procedure with no downtime or scars
  • Natural-looking results that gradually dissolve with no residue left behind

How much does smile line filler program cost?

The price of the filler injection program (per 1 cc) varies depending on the brand and type of filler used, as follows:
Neuramis Filler Program
  • Neuramis Deep
    • 1cc 4,490 THB
  • Neuramis Volume
    • 1cc 4,990 THB
Restylane Filler Program
  • Restylane Classic
    • 1cc 8,990 THB
  • Restylane Vital Light
    • 1cc 9,490 THB
  • Restylane Lyft
    • 1cc 9,490 THB
  • Restylane Defyne
    • 1cc 9,990 THB
  • Restylane Kysse
    • 1cc 9,990 THB
Juvederm Filler Program
  • Juvederm Ultra XC
    • 1cc 8,990 THB
  • Juvederm Ultra Plus XC
    • 1cc 9,490 THB
  • Juvederm Volift
    • 1cc 9,990 THB
  • Juvederm Voluma
    • 1cc 11,990 THB

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How to choose a reliable clinic for filler programs

With so many clinics available, it’s important to choose the best for safety, value, and beautiful results. So you won’t be disappointed later. Always consider:
  1. The clinic must have a valid medical facility license.
  2. The doctor must hold a verified medical license.
  3. Only genuine products from authorized distributors should be used.
  4. Every case must be assessed by a doctor before injection.
  5. Staff should explain procedures and aftercare clearly.
  6. Look for real customer reviews and recommendations from trusted people.
At MEGA CLINIC, safety and quality always come first. Every procedure is performed by experienced doctors using only verifiable, genuine filler programs—ensuring natural, confident results every time.
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FAQ: Common questions about smile line filler injection program

Q: Do smile line filler programs hurt? Will there be swelling?

A: Filler programs are much less painful than most people expect. During the procedure, cold compresses are used, and most filler programs already contain lidocaine (a numbing agent). If needed, numbing cream can also be applied.
Some mild swelling may appear in the first 7–14 days, which is normal before the HA fully settles.

Q: I just got a smile line filler program and feel small lumps. Is that normal?

A: It’s common to feel small bumps or firmness right after treatment. Over the next 4 weeks, the HA gradually integrates into the skin, becoming smooth and natural.

Q: Will smile line filler program make my cheeks look big or puffy?

A: Filler programs are injected only into the folds to smooth and lift the skin, not to enlarge the cheeks. An experienced doctor will carefully select the type and amount to ensure natural results, leaving your face looking refreshed, not overfilled.

Q: Can I combine smile line filler program with the Ultraformer III program?

A: Yes. If suitable, your doctor may recommend combining both. Filler program plumps and smooths the deep folds, while Ultraformer III tightens sagging skin. Together, they deliver stronger results: youthful contours, softened folds, firmer skin, and prevention of deeper lines in the future.

Q: Smile line filler program vs. HArmonyCa program—which is better?

A: HArmonyCa program contains both HA and CaHA, so it not only fills and lifts but also stimulates long-term collagen production. Results can last up to 18 months.
If you want fast improvement, a regular HA filler program is often enough. But if you’re looking for longer-lasting results and stronger skin support, the HArmonyCa program may be the better option. A doctor’s consultation is essential to decide the most suitable choice.

Recommended clinics for smile line filler programs in Bangkok and nearby areas

MEGA CLINIC has multiple locations covering key areas in Bangkok and nearby provinces:
  • MEGA CLINIC Siam Square (Bangkok)
    BTS Siam, located at the open area near Inter Restaurant Parking available in front of the clinic
  • MEGA CLINIC Central WestGate (Nonthaburi)
    MRT Talad Bang Yai, located on 2nd floor, Central Westgate (Central zone)
  • MEGA CLINIC Central Ladprao (Bangkok)
    BTS Ha Yaek Lat Phrao / MRT Phahon Yothin Located on 9th floor, Central Ladprao (Use Entrance C elevator)
  • MEGA CLINIC Future Park Rangsit (Pathum Thani)
    Located on G floor, Future Rangsit (Robinson zone, next to Watsons)
  • MEGA CLINIC Pak Nam BTS Srinagarindra (Samut Prakarn)
    BTS Srinagarindra, next to Exit 4 staircase Parking available in front of the clinic
Our clinic is easy to reach (view maps) and offers a full range of beauty treatments, including filler programs, Botox programs, skincare, facial lifting programs, anti-aging solutions, and even weight-loss programs. We also provide free consultations with doctors before you decide on any treatment.
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For more details or to book an appointment, message our admin team via LINE Official: @megaclinic (with @). Click the green “Add LINE” button at the bottom of the screen.